Eicosanoids and ovulation

Prostaglandins Leukot Essent Fatty Acids. 1993 Nov;49(5):827-31. doi: 10.1016/0952-3278(93)90204-a.

Abstract

PGs and probably other eicosanoids play a fundamental role in the process of ovulation, more specifically in the mechanism of follicle wall rupture. Although the nature of this role has yet to be established a number of plausible theories exist. It seems likely that altered PG metabolism is responsible for some cases of human female subfertility. The potential for fertility control by PG inhibition is an exciting possibility for the future.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Eicosanoids / antagonists & inhibitors
  • Eicosanoids / physiology*
  • Female
  • Gonadotropins, Pituitary / physiology
  • Humans
  • Hypothalamo-Hypophyseal System / drug effects
  • Hypothalamo-Hypophyseal System / physiology
  • Indomethacin / pharmacology
  • Mammals / physiology
  • Muscle Contraction
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology
  • Ovarian Follicle / drug effects
  • Ovarian Follicle / enzymology
  • Ovarian Follicle / physiology*
  • Ovulation / drug effects
  • Ovulation / physiology*
  • Prostaglandin Antagonists / pharmacology
  • Rabbits
  • Rats
  • Reactive Oxygen Species

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Eicosanoids
  • Gonadotropins, Pituitary
  • Prostaglandin Antagonists
  • Reactive Oxygen Species
  • Indomethacin