Abstract
D-phenylalanine, bacitracin and puromycin produce long-lasting, naloxone-reversible analgesia in mice. Analgesic potency parallels potency of these compounds as inhibitors of met-enkephalin degradation by mouse brain enzymes. D-phenylalanine potentiates acupuncture analgesia in mice and humans and has been used to ameliorate a variety of human chronic pain conditions.
MeSH terms
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Acupuncture Therapy
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Analgesia
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Analgesics*
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Animals
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Bacitracin / pharmacology*
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Brain / enzymology
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Drug Synergism
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Endorphins / metabolism
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Enkephalin, Methionine / pharmacology
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Humans
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Kinetics
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Mice
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Naloxone / pharmacology
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Neprilysin
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Pain, Intractable / therapy
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Phenylalanine / pharmacology*
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Protease Inhibitors*
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Puromycin / pharmacology*
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Stereoisomerism
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beta-Endorphin
Substances
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Analgesics
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Endorphins
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Protease Inhibitors
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Bacitracin
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Naloxone
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Phenylalanine
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Puromycin
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Enkephalin, Methionine
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beta-Endorphin
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Neprilysin