Testosterone Therapy for Female Sexual Dysfunction

Introduction: Female sexual dysfunction (FSD) is a common condition that affects 9% to 43% of the female population. Some studies have found that over 50% of women suffer from FSD. Testosterone has been prescribed to women for decades throughout the world and has more recently been used to treat women with FSD. Currently, testosterone is not FSA approved in the United States and is used off-label in women.

Aim: The aim of this study is to provide an overview of the current literature regarding the use of testosterone therapy (TTh) for the treatment of FSD.

Methods: PubMed searches through 2014 were conducted using terms "female sexual dysfunction," "testosterone," and "androgens." Expert opinion was based on review of the relevant scientific and medical literature.

Main outcome measures: Treatment of FSD with TTh from peer-reviewed published literature was assessed. In addition, diagnosis, treatment options, and adverse effects of TTh were also assessed.

Results: The use of testosterone has been shown to improve components of FSD including sexual desire, arousal, pleasure, and overall satisfaction. While there can be adverse effects associated with TTh such as acne and hirsutism, there are no compelling data to support that TTh causes any type of cancers, such as breast cancer or endometrial cancer.

Conclusion: TTh appears to be safe and effective in improving FSD. Khera M. Testosterone therapy for female sexual dysfunction. Sex Med Rev 2015;3:137-144.