Abstract
In the course of our search for antimalarial leads from marine algae, four metabolites, sargaquinoic acid, sargahydroquinoic acid, sargaquinal and fucoxanthin, were isolated from the South African alga Sargassum heterophyllum. Fucoxanthin and sargaquinal showed good antiplasmodial activity toward a chloroquine-sensitive strain (D10) of Plasmodium falciparum (IC50 1.5 and 2.0 microM, respectively), while sargaquinoic acid and sargahydroquinoic acid were only moderately active (IC50 12.0 and 15.2 microM, respectively).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / chemistry
-
Antimalarials / isolation & purification*
-
Antimalarials / pharmacology*
-
Benzoquinones / chemistry
-
Benzoquinones / isolation & purification
-
Benzoquinones / pharmacology
-
Cell Survival / drug effects
-
Magnetic Resonance Spectroscopy
-
Methanol
-
Models, Molecular
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plasmodium falciparum / drug effects
-
Plasmodium falciparum / growth & development*
-
Sargassum / chemistry*
-
Xanthophylls / chemistry
-
Xanthophylls / isolation & purification*
-
Xanthophylls / pharmacology*
Substances
-
Antimalarials
-
Benzoquinones
-
Plant Extracts
-
Xanthophylls
-
fucoxanthin
-
2-methyl-1,4-benzoquinone
-
Methanol