Abstract
Combination intraarticular administration of Poviargol (0.5 mg/kg) and nicotinic acid (1.0 mg/kg) reduced symptoms of local and general inflammation in rats with adjuvant arthritis. We revealed a decrease in morphological signs of inflammatory degeneration of joint tissue and reduction of metabolic disorders.
MeSH terms
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Animals
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Arthritis, Experimental / pathology*
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Drug Synergism
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Flow Cytometry
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Glycosaminoglycans / metabolism
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Inflammation / drug therapy*
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Injections, Intra-Articular
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Knee Joint / drug effects
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Knee Joint / pathology*
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Male
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Niacin / administration & dosage*
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Rats
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Silver Compounds / administration & dosage*
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Synovial Membrane / pathology
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Uronic Acids / metabolism
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Vasodilator Agents / administration & dosage
Substances
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Glycosaminoglycans
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Silver Compounds
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Uronic Acids
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Vasodilator Agents
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poviargol
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Niacin