Brahmi Rasayan, an Ayurvedic preparation, was studied in rodents for its antiinflammatory effects at po doses ranging between 1 and 10 g/kg. The drug suppressed various experimentally induced inflammatory reactions and did not show any gastric irritation in antiinflammatory doses. It is suggested that it may partially mediate its antiinflammatory activity by interfering with the action and/or synthesis of prostaglandins and also perhaps by stabilization of the lysosomal membranes. Its antiinflammatory activity is comparable to that of indomethacin.