Abstract

Background: Pancreatic cancer is the fourth most common cause of cancer related deaths in the world. Surgical resection remains the only potentially curative treatment for adenocarcinoma of the pancreas; only 10% - 20% of patients are candidate for standard pancreatic resection. Objective: To evaluate perioperative mortality, morbidity and survival for patients underwent PD in middle-volume center. Patients and Methods: Sixty patients with pancreatic tumors were enrolled in this study for different surgical procedure according to type of tumors. Results: No early postoperative complications were observed in 60% of patients, whereas 40% of patients developed one or more complication, the median survival for this group was 12.3 months with standard deviation 3.8 months.

Keywords

Pancreatic Cancer; Whipple; Complication; Survival

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1. Introduction

Pancreatic cancer is a deadly disease. In 2007, death due to pancreatic cancer is projected to approximate the incidence of the disease, with about 34,000 patients being diagnosed with pancreatic cancer in the United States [1].

The prognosis of patients with pancreatic cancer remains poor. Patients frequently present with distant metastases, which are often occult at the time of diagnosis and the 5-year survival rate is 5.6% for all patients diagnosed with pancreatic adenocarcinoma. Treatment for patients with potentially curable disease remains challenging, and the 5-year survival for patients with early stage disease is estimated at 15%, with median survival for patients with locally advanced disease remains limited at 6 to 11 months [2].

Advances in operative technique and patient care have limited perioperative morbidity and mortality for those fortunate enough to undergo resection. Nonetheless, surgical therapy (i.e. pancreatectomy) despite curative intent results in high rates of recurrence and disappointing median survivals of about 12 months [3].

The morbidity related to PD is still high, even in high-volume centers, although there has been improvement in the management of complications [4].

So in this study we evaluate perioperative mortality, morbidity and survival for patients underwent PD in middle-volume center.

2. Patient and Methods

This study was conducted at Surgical Oncology Unit, Oncology Centre, Mansoura University (OCMU) during the period between January 2005 & January 2012. Sixty patients with pancreatic tumors were enrolled in this study for different surgical procedure according to type of tumors.

Our inclusion criteria were operable pancreatic tumors candidates for surgery and exclusion criteria were metastatic cancer pancreas and celiac trunk encasement.

The following factors were analyzed: Patient demographics, intraoperative factors, as type of resection, blood loss, blood transfusion, and operative time, Tumor characteristics, including diameter, histologic grade, lymph node status and finally the primary outcome variable analyzed was survival. Follow-up was performed by office records, telephone contact; Survival was analyzed by the method of Kaplan and Meier test.

3. Results

Table 1 summarizes the patients characteristics and operative details.

Conflicts of Interest

The authors declare no conflicts of interest.

References