Dr. Jack Wing Tak Wong
Stanford University School of Medicine, USA
Email: jack_wingtak@yahoo.com
Qualifications
2010 Postdoctoral Fellow, Stanford School of Medicine, USA
2010 Postdoctoral Fellow, School of Biomedical Sciences, Chinese
University of Hong Kong, Hong Kong, China
2009 Ph.D., Physiology, Department of Physiology, Faculty of
Medicine, Chinese University of Hong Kong, Hong Kong, China
2005 B.Sc., Chinese Medicine and Bachelor of Biomedical Sciences,
Hong Kong Baptist University, Hong Kong, China
Publications(Selected)
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Sayed
N, *Wong WT, Ospino F, Meng S, Lee J, Jha A, Dexheimer P, Aronow B, Cooke JP
(2015). Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of
Innate Immunity. Circulation. 131(3):300-9. *Co-first author.
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Liu
J, Wang L, Tian X, Liu L, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen
Z, Yu J, Ng CF, Yao X, Huang Y (2015). Unconjugated bilirubin mediates heme
oxygenase-1-induced vascular benefits in diabetic mice. Diabetes. In Press.
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Cheang
WS, Tian XY, Wong WT, Huang Y (2015). Peroxisome proliferator-activated
receptors in cardiovascular diseases: experimental benefits and clinical
challenges. British Journal Pharmacology. In Press.
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Cooke
JP, Sayed N, Lee J, Wong WT (2014). Innate immunity and epigenetic plasticity
in cellular reprogramming. Current Opinion in Genetics & Development.
28:89-91.
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Cheang
WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & Huang Y
(2014) Metformin protects endothelial function in diet-Induced obese mice by
inhibition of endoplasmic reticulum stress through AMPK-PPARδ pathway.
Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6.
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Zhang
Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo J, Cheang WS, Lau CW, Kwan KM,
Wang N, Yao X, Huang Y (2014). Inhibition of Bone Morphogenic Protein 4 Restores
Endothelial Function in db/db Diabetic Mice. Arterioscler Thromb Vasc Biol.
34(1):152-159.
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Wong
WT, Tian XY, Huang Y (2013). Endothelial Dysfunction in Diabetes and
Hypertension: Cross Talk in RAS, BMP4 and ROS-dependent COX-2-derived
Prostanoids. J Cardiovascular Pharmacology 61(3):204-14
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Cheang
WS, Lam MY, Wong WT, Tian XY, Zhu Z, Yao X, Huang Y (2013) Menthol relaxes rat
aortae, mesenteric and coronary arteries by blocking L-type calcium channels.
European Journal of Pharmacology (1-3):79-84.
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Yung
LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao X, Huang Y
(2013). Chronic consumption of cranberry juice restores cholesterol profiles
and endothelial function during estrogen deficiency. European Journal of
Nutrition 52(3):1145-55.
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Tian
XY, *Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY,
Cooke JP, Yao X, Huang Y (2012). PPARδ activation protects endothelial function
in diabetic mice. Diabetes 61(12):3285-93(*Co-first author)
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Liu
L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu ZM, Xu A, Lam KS,
Chen ZY, Ng CF, Yao X, Huang Y (2012). Dipeptidyl Peptidase-4 Inhibitor
Sitagliptin Protects Endothelial Function in Hypertension through GLP-1
Dependent Mechanism. Hypertension 60(3):833-41
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Wong
WT, Huang NF, Botham CM, Sayed N, Cooke JP (2012). Endothelial cells derived
from nuclear reprogramming. Circulation Research 2012;111(10):1363-75.
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Tian
XY, *Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y
(2012).
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Uncoupling
Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice. Circulation
Research 110(9):1211-6. (*Co-first author)
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Tian
XY, *Wong WT, Wang YX, Leung FP, Ng CF, Wang YX, Lee HK, Yao X, Au CL, Lau CW,
Vanhoutte PM, Cooke JP, Huang Y (2012) ROS-stimulated production of cyclooxygenase-2-derived
prostaglandin F2 cause endothelial dysfunction and impaired renal blood flow
in renovascular hypertensive rats. Antioxidant & Redox Signaling
16(4):363-73. (*Co-corresponding author)
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Tian
XY, Yung LH, Wong WT, Leung FP, Chen YC, Kong SK, Ng SM, Lai PB, Yung LM, Yao X
& Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell
apoptosis through oxidative stress-dependent
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p38MAPK
and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-44
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Tian
XY, Wong WT, Sayed N, Lau CW, Luo J, Tsang SY, Leung FP, Bian ZX, Yao X, Chen
ZY, Huang Y (2012) NaHS relaxes rat and mouse cerebral artery through
inhibition of L-type Ca2+ channels. Pharmacological Research 65(20:239-246
(Co-corresponding author)
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Leung
JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK
(2011).
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Transgenic
Mice Over-Expressing ET-1 in the Endothelial Cells Develop Systemic
Hypertension with Altered Vascular Reactivity. PLoS One 6(11):e26994.
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Cheang
WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y (2011) Endothelial
nitric oxide synthase enhancer reduces oxidative stress and restores
endothelial function in db/db mice. Cardiovascular Research 92(2):267-75.
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Wong
WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM,
Huang Y (2011) Adiponectin is required for PPARγ-mediated improvement of
endothelial function in diabetic mice. Cell Metabolism 2011;14(1):104-15.
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*Wong
WT, Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte
PM, Tipoe GL, Huang Y (2010). Bone morphogenic protein-4 impairs endothelial
function through oxidative stress-dependent cyclooxygenase-2 upregulation:
implications on hypertension. Circulation Research 107(8):984-91
(*Cocorresponding author)
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Wong
WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y (2010).
Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial
dysfunction in diabetic mice. Antioxidants & Redox Signaling
15;13(6):757-68.
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Tian
XY, Wong WT, Xu A, Chen ZY, Liu L, Cheang WS, Lee VWY, Lau CW, Yao X &
Huang Y (2011) Rosuvastatin Improves Endothelial Function of db/db Mice: Role
of Angiotensin II Type 1 Receptors and Oxidative Stress. British Journal of
Pharmacology 164(2b):598-606.(Co-corresponding author).