Effect of glucomannan on obese patients: a clinical study

Int J Obes. 1984;8(4):289-93.

Abstract

An eight-week double-blind trial was conducted to test purified glucomannan fiber as a food supplement in 20 obese subjects. Glucomannan fiber (from konjac root) or placebo was given in 1-g doses (two 500 mg capsules) with 8 oz water, 1 h prior to each of three meals per d. Subjects were instructed not to change their eating or exercise patterns. Results showed a significant mean weight loss (5.5 lbs) using glucomannan over an eight-week period. Serum cholesterol and low-density lipoprotein cholesterol were significantly reduced (21.7 and 15.0 mg/dl respectively) in the glucomannan treated group. No adverse reactions to glucomannan were reported.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Body Weight / drug effects
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Clinical Trials as Topic
  • Diet, Reducing*
  • Dietary Fiber / therapeutic use*
  • Double-Blind Method
  • Female
  • Food, Fortified*
  • Humans
  • Mannans / pharmacology*
  • Mannans / therapeutic use
  • Obesity / diet therapy*
  • Triglycerides / blood

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dietary Fiber
  • Mannans
  • Triglycerides
  • (1-6)-alpha-glucomannan
  • Cholesterol