Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.

Morganti P; Berardesca E; Guarneri B; Guarneri F; Fabrizi G; Palombo P; Palombo M

doi:10.1111/j.1468-2494.2011.00658.x

Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.

Affiliations

1. Applied Cosmetic Dermatology, II University of Naples, Italy.
Authors
Morganti P¹
(1 author)

ORCIDs linked to this article

Berardesca E | 0000-0003-3423-5038

International Journal of Cosmetic Science, 13 Jun 2011, 33(5):467-476
https://doi.org/10.1111/j.1468-2494.2011.00658.x PMID: 21668835

Abstract

It has been shown that topical linoleic acid rich-phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improvement.

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Goh CL, Noppakun N, Micali G, Azizan NZ, Boonchai W, Chan Y, Cheong WK, Chiu PC, Etnawati K, Gulmatico-Flores Z, Foong H, Kubba R, Paz-Lao P, Lee YY, Loo S, Modi F, Nguyen TH, Nguyen TH, Pham TL, [...] Wong SN
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Search life-sciences literature (44,010,547 articles, preprints and more)

Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Title not supplied

Topical vitamin A acid in acne vulgaris

Essential fatty acids and acne.

Androgen control of the pilosebaceous duct?

Increased superoxide generation by normal granulocytes incubated in sera from patients with psoriasis

Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects.

Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis.

The role of the antioxidative defense system in papulopustular acne.

Antioxidant activity, lipid peroxidation and skin diseases. What’s new

Phyiopathology of acne vulgaris: recent data, new understanding of the treatments

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1468-2494.2011.00658.x

Article citations

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.

In Situ Gel Formation in Microporated Skin for Enhanced Topical Delivery of Niacinamide.

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.

The role of nicotinamide in acne treatment.

Meeting the Challenges of Acne Treatment in Asian Patients: A Review of the Role of Dermocosmetics as Adjunctive Therapy.

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Search life-sciences literature (44,010,547 articles, preprints and more)

Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial.

Author information

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Title not supplied

Topical vitamin A acid in acne vulgaris

Androgen control of the pilosebaceous duct?

Increased superoxide generation by normal granulocytes incubated in sera from patients with psoriasis

Antioxidant activity, lipid peroxidation and skin diseases. What’s new

Phyiopathology of acne vulgaris: recent data, new understanding of the treatments

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

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